| September 19, 2021 | ||
| Tottenham Hotspur | 0 - 3 | Chelsea |
| West Ham United | 1 - 2 | Manchester United |
| Brighton & Hov… | 2 - 1 | Leicester City |
| September 18, 2021 | ||
| Aston Villa | 3 - 0 | Everton |
| Norwich City | 1 - 3 | Watford |
| Manchester City | 0 - 0 | Southampton |
| Liverpool | 3 - 0 | Crystal Palace |
| Burnley | 0 - 1 | Arsenal |
| Wolverhampton Wanderers | 0 - 2 | Brentford |
| September 17, 2021 | ||
| Newcastle United | 1 - 1 | Leeds United |
| September 13, 2021 | ||
| Everton | 3 - 1 | Burnley |
| September 12, 2021 | ||
| Leeds United | 0 - 3 | Liverpool |
| September 11, 2021 | ||
| Chelsea | 3 - 0 | Aston Villa |
| Watford | 0 - 2 | Wolverhampton Wanderers |
| Southampton | 0 - 0 | West Ham United |
| Manchester United | 4 - 1 | Newcastle United |
| Leicester City | 0 - 1 | Manchester City |
| Brentford | 0 - 1 | Brighton & Hov… |
| Arsenal | 1 - 0 | Norwich City |
| Crystal Palace | 3 - 0 | Tottenham Hotspur |
