| April 21, 2021 | ||
| Aston Villa | 1 - 2 | Manchester City |
| Tottenham Hotspur | 2 - 1 | Southampton |
| April 20, 2021 | ||
| Chelsea | 0 - 0 | Brighton & Hov… |
| April 19, 2021 | ||
| Leeds United | 1 - 1 | Liverpool |
| April 18, 2021 | ||
| Manchester United | 3 - 1 | Burnley |
| Arsenal | 1 - 1 | Fulham |
| April 17, 2021 | ||
| Wolverhampton Wanderers | 1 - 0 | Sheffield United |
| Newcastle United | 3 - 2 | West Ham United |
| April 16, 2021 | ||
| Everton | 2 - 2 | Tottenham Hotspur |
| April 12, 2021 | ||
| Brighton & Hov… | 0 - 0 | Everton |
| West Bromwich Albion | 3 - 0 | Southampton |
| April 11, 2021 | ||
| Sheffield United | 0 - 3 | Arsenal |
| Tottenham Hotspur | 1 - 3 | Manchester United |
| West Ham United | 3 - 2 | Leicester City |
| Burnley | 1 - 2 | Newcastle United |
| April 10, 2021 | ||
| Crystal Palace | 1 - 4 | Chelsea |
| Liverpool | 2 - 1 | Aston Villa |
| Manchester City | 1 - 2 | Leeds United |
| April 9, 2021 | ||
| Fulham | 0 - 1 | Wolverhampton Wanderers |
