Friday, October 1, 2010
Uniao de Leiria 2 - 1 Académica de Coimbra

Saturday, October 2, 2010
Olhanense 3 - 1 Vitoria Setubal

Sunday, October 3, 2010
CD Nacional de Madeira 3 - 1 Portimonense
Naval 1º Maio 1 - 2 Paços de Ferreira
Rio Ave 0 - 0 Maritimo
Benfica 1 - 0 Braga

Monday, October 4, 2010
Beira-Mar 1 - 1 Sporting Lisbon
Guimaraes 1 - 1 FC Porto

Saturday, October 23, 2010
Académica de Coimbra 2 - 1 CD Nacional de Madeira
Paços de Ferreira 1 - 1 Beira-Mar
Vitoria Setubal 2 - 1 Guimaraes
Braga 3 - 1 Olhanense

Sunday, October 24, 2010
Maritimo 1 - 0 Naval 1º Maio
Sporting Lisbon 1 - 0 Rio Ave
Portimonense 0 - 1 Benfica

Monday, October 25, 2010
FC Porto 5 - 1 Uniao de Leiria

Friday, October 29, 2010
Benfica 2 - 0 Paços de Ferreira

Saturday, October 30, 2010
Rio Ave 2 - 0 Braga
Académica de Coimbra 0 - 1 FC Porto

Sunday, October 31, 2010
Beira-Mar 3 - 1 Naval 1º Maio
CD Nacional de Madeira 1 - 0 Vitoria Setubal
Olhanense 1 - 1 Maritimo
Uniao de Leiria 1 - 2 Sporting Lisbon